Transporteurs d'iodures et fonction thyroïdienne

Thyroid function is strongly associated with blood iodide essential for biosynthesis of thyroid hormones. After its uptake at the basolateral plasma membrane, iodide is translocated to the follicular lumen for the thyroid hormonal biosynthesis. Iodide metabolism in the thyrocyte has been reinvestigated by the recent discovery of three new proteins (sodium-iodide symporter or NIS, pendrin and apical iodide transporter or AIT) which have been involved in the iodide transport. In this work, we have reported the recent structural and metabolic studies concerning these three proteins.