Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-ÎºB and HMGB1

Article ID	Journal	Published Year	Pages	File Type
8472056	Immunobiology	2018	31 Pages	PDF

Abstract

Taken together, TxTÂ +Â H/R induced strong inflammatory response and apoptotic changes as well as lung injury which were markedly diminished by EP. Our results suggest that this might be mediated via NF-ÎºB and/or HMGB1 dependent mechanism.

Keywords

BPA TNF ICAM BAL μL PAMP CAE qRT-PCR pCO2 DAMP GAPDH HMGB1 MOF PO2 NF-κB PMNL LPS Bcl dFG DNA °C Ethyl pyruvate Resuscitation p-value deoxyribonucleic acid ribonucleic acid RNA interleukin Blunt thoracic trauma ELISA Enzyme-linked immunosorbent assay Mercury Min Apoptosis standard error of the mean Percent minute Room temperature Second Lung Hour Celsius Hemorrhagic shock Multiple organ failure tumor necrosis factor nuclear factor kappa-light-chain-enhancer of activated B cells Partial pressure of oxygen Partial pressure of carbon dioxide mean arterial pressure lactate dehydrogenase LDH B-cell lymphoma polymorphonuclear leukocytes liter lipopolysaccharide Bronchoalveolar lavage fluid SEM intercellular adhesion molecule milliliter milligram Microliter map Neutrophils Necrosis hematoxylin-eosin unit body weight High mobility group box 1 protein Pyruvate chloroacetate esterase kilogram glyceraldehyde 3-phosphate dehydrogenase