Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8472136 | Immunobiology | 2009 | 17 Pages |
Abstract
Although the connection between inflammation and cancer is unequivocal the mechanistic basis of such association are largely unknown. Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed.
Keywords
angiopoietin-27,12-dimethyl-benz[a]anthraceneTEMSTNFalphaColony-stimulating factor-1cycloxygenase-2TAMsCSF-1MDSCMDSCsSTAT-3GM-CSFTLRDMBAPGE2TGFβNSAIDSNF-κBMmpsROIHIF-1COX-2STATsAng-2inflammationtransforming growth factor-βtumour necrosis factor alphatumour-associated macrophagesToll-like receptorNonsteroidal anti-inflammatory drugsCancerMyeloid-derived suppressor cellsCytokineshypoxia inducible factor 1granulocyte-macrophage colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)MetalloproteinaseNitric oxideReactive oxygen intermediates
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Authors
Chiara Porta, Paola Larghi, Monica Rimoldi, Maria Grazia Totaro, Paola Allavena, Alberto Mantovani, Antonio Sica,