| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473391 | Journal of Molecular and Cellular Cardiology | 2018 | 36 Pages |
Abstract
In conclusion, BPF reduces DOXO-induced cardiotoxicity by counteracting reactive oxygen species (ROS) overproduction, thereby restoring protective autophagy and attenuating cardiomyocyte apoptosis and pathologic remodeling. This beneficial effects on the early toxicity of DOXO is associated with enhanced CSCs survival and regenerative potential. Overall these data point to a potential clinical role by diet supplementation with polyphenol-rich fraction of citrus bergamot in counteracting antracycline-induced cardiomyopathy.
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Authors
Cristina Carresi, Vincenzo Musolino, Micaela Gliozzi, Jessica Maiuolo, Rocco Mollace, Saverio Nucera, Alessia Maretta, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Ernesto Palma, Francesca Bosco, Caterina Giancotta, Carolina Muscoli, Fabiola Marino,