| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473524 | Journal of Molecular and Cellular Cardiology | 2018 | 10 Pages |
Abstract
In hypertensive ZSF-1 rats, a possibly compensatory increase of cytosolic CaT amplitude and increased SR Ca leak precede atrial remodeling and HFpEF. Atrial remodeling in ZSF-1 HFpEF is associated with an altered tubular network in-vitro and atrial contractile dysfunction in vivo, indicating insufficient compensation. Atrial cardiomyocyte dysfunction in vitro is induced by the addition of angiotensin II.
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Authors
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M. Pieske, Frank R. Heinzel,