Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473537 | Journal of Molecular and Cellular Cardiology | 2018 | 33 Pages |
Abstract
In summary, deletion of IL-17 is able to mitigate myocardial fibrosis and improve cardiac function of diabetic mice. The IL-17/AK081284/TGFβ1 signaling pathway mediates high glucose induced collagen production. This study indicates the therapeutic potential of IL-17 inhibition on diabetic cardiomyopathy disease associated with fibrosis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Yang Zhang, Yi-Yuan Zhang, Ting-Ting Li, Jin Wang, Yuan Jiang, Yue Zhao, Xue-Xin Jin, Gen-Long Xue, Ying Yang, Xiao-Fang Zhang, Yang-Yang Sun, Zhi-Ren Zhang, Xu Gao, Zhi-Min Du, Yan-Jie Lu, Bao-Feng Yang, Zhen-Wei Pan,