| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473594 | Journal of Molecular and Cellular Cardiology | 2018 | 11 Pages |
Abstract
Our results demonstrate that JNK is a critical regulator of Cx43 expression, and that augmented JNK activation in aged atria downregulates Cx43 to impair cell-cell communication and promote the development of AF. JNK inhibition may represent a promising therapeutic approach to prevent or treat AF in the elderly.
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Authors
Jiajie Yan, Justin K. Thomson, Weiwei Zhao, Xiaomin Wu, Xianlong Gao, Dominic DeMarco, Wei Kong, Min Tong, Jun Sun, Mamdouh Bakhos, Vladimir G. Fast, Qingrong Liang, Sumanth D. Prabhu, Xun Ai,