| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473684 | Journal of Molecular and Cellular Cardiology | 2016 | 31 Pages |
Abstract
The core protein of exogenous biglycan protects myocardial cells from SI/R injury via TLR4-mediated mechanisms involving activation of ERK, JNK and p38 MAP kinases and increased NO production. The cytoprotective effect of rhBGNc is due to modulation of SI/R-induced changes in necrosis, apoptosis and autophagy.
Keywords
TGFβSI/RJun N-terminal kinaseTLR4D-PBSGAGRIPASTAT3HRPGAPDHESRFBSDMEMBSADulbecco's modified Eagle MediumERK1/2l-NAMENω-nitro-l-arginine methyl ester hydrochloridebovine serum albuminAktradioimmunoprecipitation assay bufferBrdUSAFEtransforming growth factor-betareperfusion injury salvage kinaseRiskRoom temperaturedihydroethidiumfetal bovine serumElectron spin resonance spectroscopyDulbecco's phosphate-buffered salinesignal transducer and activator of transcription 3Nitric oxideDHEHorseradish peroxidaseProteoglycanprotein kinase Bmitogen activated protein kinaseglyceraldehyde 3-phosphate dehydrogenaseGlycosaminoglycanToll-like receptor 4
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Authors
Renáta Gáspár, Márton Pipicz, Fatime Hawchar, Dávid Kovács, Luna Djirackor, Anikó Görbe, Zoltán V. Varga, Mónika Kiricsi, Goran Petrovski, Attila Gácser, Csaba Csonka, Tamás Csont,