Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473685 | Journal of Molecular and Cellular Cardiology | 2016 | 38 Pages |
Abstract
Our computer modeling approach based on experimental data, yields results that suggest that selective inhibition of INaL modifies all TRIaD related parameters arising from acquired Long-QT Syndrome, and thereby reduced arrhythmia risk. This study reveals the potential for adjunctive pharmacotherapy via targeted block of INaL to mitigate proarrhythmia risk for drugs with significant but unintended off-target hERG blocking effects.
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Authors
Pei-Chi Ph.D., Nesrine Ph.D., Lucia Ph.D., Wayne R. Ph.D., Sridharan Ph.D., Luiz M.D., Colleen E. Ph.D.,