Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473699 | Journal of Molecular and Cellular Cardiology | 2016 | 4 Pages |
Abstract
- Morphological and functional changes in VIC and VEC play crucial roles in pathogenesis (dystrophic & osteogenic) of CAVD.
- Conventional 2D matrices to study such changes are ineffective as matrix stiffness also influences VIC differentiation.
- Novel 3D hydrogel matrices with varying stiffness are emerging as useful means to study CAVD.
- With the help of biomechanics and tissue engineering, it would be possible to devise future treatment strategies for CAVD.
Keywords
VICtwist-related protein 1tef1CAVDVECTwist1TGFβRUNX2α-SMAECMTNFαEndothelial to mesenchymal transitionalpha smooth muscle actinOsteogenesiscalcific aortic valve diseaseDifferentiationtumor necrosis factor alphaEMTApoptosisValvular interstitial cellstumor growth factor betaRunt-related transcription factor 2Fibroblastextra-cellular matrixExtracellular matrix
Related Topics
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Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Malav N. Madhu, Christie Aguiar, Ansar Hassan, Keith R. Brunt,