| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473704 | Journal of Molecular and Cellular Cardiology | 2016 | 9 Pages |
Abstract
Treatment with antidepressant citalopram in the acute but not in the late phase after MI significantly increased mortality in mice by disturbing early healing. Pharmacological MMP inhibition partially reversed the deleterious effects of citalopram.
Keywords
α-SMATNF αTGF β5HT2Aserotonin receptor 2ASmad3FOVCITTTCPSRFITCABCPBSDABMMPLPS3,3′-diaminobenzidineDMSOERK1/2picrosirius redSALHydrogen peroxidealpha smooth muscle actinMyocardial infarctioninterleukinRemodelingTransforming Growth Factor Betatumor necrosis factor alphaTIMPSERTserotonin transporterCitalopramAntidepressantfluorescein isothiocyanateLADlipopolysaccharidematrix metalloproteinasePhosphate-buffered salineSelective serotonin reuptake inhibitorTissue inhibitor of metalloproteinaseSSRIMiceField of viewH2O2left anterior descending coronary arteryextracellular signal-regulated kinases 1 and 2
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Authors
Anna Frey, Veronica-Maria Saxon, Sandy Popp, Marc Lehmann, Denise Mathes, Christina Pachel, Ulrich Hofmann, Georg Ertl, Klaus-Peter Lesch, Stefan Frantz,