Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Clâ current in canine ventricular myocytes

Article ID	Journal	Published Year	Pages	File Type
8473754	Journal of Molecular and Cellular Cardiology	2016	27 Pages	PDF

Abstract

Activation of ICl(Ca) in canine ventricular cells requires Ca2+-entry through neighboring L-type Ca2+ channels and is only augmented by SR Ca2+-release. Substantial activation of ICl(Ca) requires high Ca2+ concentration in the dyadic clefts which can be effectively buffered by BAPTA, but not EGTA.

Keywords

9-anthracene carboxylic acid ICl(Ca)Ca2+-dependent inactivation SITS Large-conductance Ca2+-activated K+ channels IncX TMEM16A 9-AC CaV1.2 LTCC APD90 [Cl−]i DIDS RyR HEPES PCC CDI CAT IKS DAPI DAD 4′,6-diamidino-2-phenylindole 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid BKCa ICa,L L-type Ca2+ current [Ca2+]i ISO isoproterenol standard error of the mean Sarcoplasmic reticulum Pearson correlation coefficient intracellular Cl− concentration SEM action potential delayed afterdepolarization Human cardiomyocytes L-type Ca2+ channel CICR Calcium transient Ryanodine receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Authors

Balázs Horváth, Krisztina Váczi, Bence Hegyi, Mónika Gönczi, Beatrix Dienes, Kornél Kistamás, Tamás Bányász, János Magyar, István Baczkó, András Varró, György Seprényi, László Csernoch, Péter P. Nánási, Norbert Szentandrássy,