| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473779 | Journal of Molecular and Cellular Cardiology | 2016 | 12 Pages |
Abstract
There exists a synergistic interaction between human platelets and late EPCs leading to vascular regeneration. This interaction consists of LPA from platelets and its receptor Edg-2 on the surface of EPCs and can be potentiated by PPAR-δ activation in EPCs. A PPAR-δ agonist is a good candidate to achieve vasculogenesis for ischemic vascular disease.
Keywords
ADRPPPAR response elementsPPREsEDGPPAR-δPSGL-1EBMMNCsIGFBP-3EGMECMLPAS1PMMP-9EPCCOXcyclooxygenasesphingosine 1-phosphatelysophosphatidic acidEndothelial progenitor cellsEndothelial cellsMononuclear cellsP-selectin glycoprotein ligand-1Extracellular matrixadipose differentiation-related proteinPlateletEndothelial differentiation gene
Related Topics
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Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Jung-Kyu Han, Back-Kyung Kim, Joo-Yun Won, Youngchul Shin, Saet-Byeol Choi, Injoo Hwang, Jeehoon Kang, Ho-Jae Lee, Seok-Jin Koh, Jaewon Lee, Jin Hur, Hyun-Jai Cho, In-Ho Chae, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim,