Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Article ID	Journal	Published Year	Pages	File Type
8473800	Journal of Molecular and Cellular Cardiology	2016	9 Pages	PDF

Keywords

ICA APD EAD Na+/Ca2 + exchanger NCX IKr RyR CaMKII L-type Ca2 + current intracellular Ca2 + concentration IncX DAD Ca2 +/calmodulin-dependent protein kinase II INa [Ca2 +]i ACh Use-dependent block Acetylcholine early afterdepolarization ISO isoproterenol delayed rectifier K+ current Na+ current ranolazine Sarcoplasmic reticulum pulmonary vein Atrial fibrillation Paroxysmal atrial fibrillation Action potential duration Computer model PAF action potential Membrane potential delayed afterdepolarization Ryanodine receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Authors

Stefano Morotti, Andrew D. McCulloch, Donald M. Bers, Andrew G. Edwards, Eleonora Grandi,