| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8473811 | Journal of Molecular and Cellular Cardiology | 2016 | 4 Pages |
Abstract
- All three compartments of RAS (circulating, tissue and intracellular) are critical in the pathogenesis of heart failure.
- Fibroblasts are active, not passive, endocrine regulators of ECM remodeling that are regulated by RAS.
- Fibroblasts synthesize chymase, an essential modulator of RAS activity, which affects modulating cardiac ECM.
- Only 2 of 8 drug classes are widely used to manage RAS; future therapeutics are targeting chymase as a key regulator of RAS.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Ashley L. Eadie, Jeremy A. Simpson, Keith R. Brunt,