Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473824 | Journal of Molecular and Cellular Cardiology | 2016 | 12 Pages |
Abstract
Electrophysiological measurements during exposure to ranolazine alone or in combination with low-dose dronedarone showed APD prolongation, cellular hyperpolarization and reduced SR Ca2Â + leak in human atrial myocytes. The combined inhibitory effects on various currents, in particular Na+ and K+ currents, may explain the anti-AF effects observed in the HARMONY trial. Therefore, the combination of ranolazine and dronedarone, but also ranolazine alone, may be promising new treatment options for AF, especially in patients with HF, and merit further clinical investigation.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Nico Hartmann, Fleur E. Mason, Inga Braun, Steffen Pabel, Niels Voigt, Hanna Schotola, Thomas H. Fischer, Dobromir Dobrev, Bernhard C. Danner, André Renner, Jan Gummert, Luiz Belardinelli, Norbert Frey, Lars S. Maier, Gerd Hasenfuss, Samuel Sossalla,