Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473894 | Journal of Molecular and Cellular Cardiology | 2016 | 14 Pages |
Abstract
A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases. ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are present in soluble form in the extracellular space. Dysregulated production or function of these enzymes has been associated with pathologies such as cancer, asthma, Alzheimer's and cardiovascular diseases. ADAMs contribute to angiogenesis, hypertrophy and apoptosis in a stimulus- and cell type-dependent manner. Among the ADAMs identified so far (34 in mouse, 21 in human), ADAMs 8, 9, 10, 12, 17 and 19 have been shown to be involved in cardiovascular development or cardiomyopathies; and among the 19 ADAM-TSs, ADAM-TS1, 5, 7 and 9 are important in development of the cardiovascular system, while ADAM-TS13 can contribute to vascular disorders. Meanwhile, there remain a number of ADAMs and ADAM-TSs whose function in the cardiovascular system has not been yet explored. The current knowledge about the role of ADAMs and ADAM-TSs in the cardiovascular pathologies is still quite limited. The most detailed studies have been performed in other cell types (e.g. cancer cells) and organs (nervous system) which can provide valuable insight into the potential functions of ADAMs and ADAM-TSs, their mechanism of action and therapeutic potentials in cardiomyopathies. Here, we review what is currently known about the structure and function of ADAMs and ADAM-TSs, and their roles in development, physiology and pathology of the cardiovascular system.
Keywords
HB-EGFTSRSVMPAPPMDCGPCRHVRFGFRSH3ECMTACEphorbol 12-myristate 13-acetateRECKVCAM-1LVADCOMPPDK1TTPEGFRADAM-TSTNF-alpha converting enzymePI3KMMPReversion-inducing cysteine-rich protein with kazal motifsTSP1PPCHyper-variable regionvWFERKDCMICAM-1ADAMsG protein coupled receptorPMAADAMMyocardial infarctionRemodelingHeart diseaseepithelial-to-mesenchymal transformationa disintegrin and metalloproteinaseThrombotic thrombocytopenic purpuraThrombospondin-1EMTC-domaincysteine-rich domainleft ventricular assist deviceTIMPVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Heparin-binding EGF-like growth factorPhosphatidylinositol 3-kinaseExtracellular matrixmatrix metalloproteinaseSnake venom metalloproteinaseTissue inhibitor of metalloproteinaseIntercellular adhesion molecule 1vascular cell adhesion molecule-1RIPregulated intramembrane proteolysisCartilage oligomeric matrix proteinamyloid precursor proteinSingle nucleotide polymorphismSNPDilated cardiomyopathyextracellular signal-regulated kinaseEpidermal growth factor receptorfibroblast growth factor receptor
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Authors
Pu Zhang, Mengcheng Shen, Carlos Fernandez-Patron, Zamaneh Kassiri,