Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473902 | Journal of Molecular and Cellular Cardiology | 2016 | 6 Pages |
Abstract
Heart failure (HF) is one of the leading causes of mortality in the world. Various molecular mechanisms have been proposed for HF, but its precise mechanisms are still largely unknown. In this review, summarizing the “President's Distinguished Lecture Award” of XX World Congress of International Society for Heart Research 2010 in Kyoto, Japan, we introduce recent our studies on HF, including 1) p53-induced suppression of Hif-1-induced angiogenesis as a novel mechanism of HF, 2) angiogenesis as a potential therapeutic strategy for HF, and 3) IGFBP-4 as a novel factor for cardiomyogenesis by inhibiting canonical Wnt signaling.
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Authors
Toru Oka, Hiroyuki Morita, Issei Komuro,