Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8473939 | Journal of Molecular and Cellular Cardiology | 2016 | 29 Pages |
Abstract
Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracellular matrix in the cardiac interstitium and perivascular space, leading to structural and functional detrimental changes in the heart. Cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. Understanding the molecular bases of their action could provide tools for the treatment of cardiac remodeling. This review summarizes recent evidences on non-coding RNAs, including microRNAs and long non-coding RNAs that modulate the phenotype of cardiac fibroblasts and may serve in the future as targets for novel therapeutic strategies against cardiac fibrosis.
Keywords
ECMEndMTalpha-SMADGCR8MEG3ncRNAslncRNAscdkn1cFSP1CTGFFGFSpry1TNF-alphaMmpsCFSmiRNAsSMembDdr2Long non-coding RNAsnon-coding RNAsTGF-betaalpha smooth muscle actinMyocardial infarctionAngiotensin IIendothelial-mesenchymal transitioninterleukin 1-betatransforming growth factor-betatumor necrosis factor-alphaEMTAng IImicroRNAsLong noncoding RNAConnective tissue growth factorfibroblast growth factorcardiac fibroblastsCardiac fibrosisExtracellular matrixMatrix metalloproteinasesMicroRNAheart failureFibroblast specific protein 1maternally expressed gene 3PtenEpithelial-mesenchymal transitionAngiotensin II receptorDiscoidin domain receptor 2
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Authors
Maria-Teresa Piccoli, Christian Bär, Thomas Thum,