| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474046 | Journal of Molecular and Cellular Cardiology | 2015 | 13 Pages |
Abstract
Our study provides the first evidence that sustained selective EPAC activation leads to an increase in TRPC3 and C4 protein expression and induces a proarrhythmic SOCE-like activity in adult rat ventricular cardiomyocytes, which might be of importance during the development of cardiac diseases.
Keywords
SDSExchange protein directly activated by cyclic AMPTRPCLTCCKB-R7943Store-operated Ca2+ entry (SOCE)nIFNCXEpacSOCEThapsigarginRyRpKa3′,5′-cyclic adenosine monophosphatecAMPNa+/Ca2+ exchangerSarcoplasmic reticulumsodium dodecyl sulfateCardiomyocyteNifedipineStore-operated Ca2+ entrytransient receptor potential canonicalprotein kinase AL-type Ca2+ channelRyanodine receptor
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Authors
Alejandro DomÃnguez-RodrÃguez, Gema Ruiz-Hurtado, Jessica Sabourin, Ana Maria Gómez, Julio L. Alvarez, Jean-Pierre Benitah,