| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474189 | Journal of Molecular and Cellular Cardiology | 2015 | 10 Pages |
Abstract
We describe here for the first time that overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy. This effect was mediated by HSP-90 induced stabilization of HIF-1 alpha. Further work is needed to understand this unexpected cardioprotective effect of calcineurin A.
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Authors
Sabine Eschricht, Kai-Uwe Jarr, Christian Kuhn, Lorenz Lehmann, Michael Kreusser, Hugo A. Katus, Norbert Frey, Emmanuel Chorianopoulos,