Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8474242 | Journal of Molecular and Cellular Cardiology | 2015 | 11 Pages |
Abstract
Heart failure is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or the ejection of blood, and is a leading cause of morbidity and mortality in industrialized countries. The mechanisms underlying the development of heart failure are multiple, complex and not well understood. Cardiac mass and its homeostasis are maintained by the balance between protein synthesis and degradation, and an imbalance is likely to result in cellular dysfunction and disease. The protein degradation systems are the principle mechanisms for maintaining cellular homeostasis via protein quality control. Three major protein degradation systems have been identified, namely the calpain system, autophagy, and the ubiquitin proteasome system. Proinflammatory mediators involve the development and progression of heart failure. DNA and RNA degradation systems play a critical role in regulating inflammation and maintaining cellular homeostasis mediated by damaged DNA clearance and posttranscriptional regulation, respectively. This review discusses some recent advances in understanding the role of these degradation systems in heart failure.
Keywords
LAMP2IκBCaMKGPCRTLRATGAMPKASK1CRYABStat6TTPIKKMK2TREX1KSRPTNFKH-type splicing regulatory proteinCa2 +/calmodulin-dependent protein kinaseHu-antigen RMG53mitsugumin 53AUFdeoxyribonucleaseBRFNF-κBNEMODRCTACAMP-activated protein kinaseMitochondrial DNADNAseI/RIκB kinaseROSαB-crystallinAutophagyinflammationischemia/reperfusioninterleukinTristetraprolinToll-like receptormtDNAUbiquitin proteasome systemAU-rich elementtumor necrosis factornuclear factor-κBSystemic lupus erythematosusSLESignal transducer and activator of transcription 6NF-κB essential modulatorautophagy-relatedUTR یا untranslated regions untranslated regioninhibitor of NF-κBMicroRNAMiRNAheart failuremapARElysosome-associated membrane protein 2mitogen-activated proteinHuRCalpainapoptosis signal-regulating kinase 1Reactive oxygen speciesG protein-coupled receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Kazuhiko Nishida, Osamu Yamaguchi, Kinya Otsu,