| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474274 | Journal of Molecular and Cellular Cardiology | 2015 | 8 Pages |
Abstract
Muscle stretch increases the velocity of Ca2Â + waves by increasing ROS production, not by increasing myofilament Ca2Â + sensitivity. In the case of SCH00013, ROS production increases myofilament Ca2Â + sensitivity and the velocity of Ca2Â + waves. These results suggest that ROS rather than myofilament Ca2Â + sensitivity plays an important role in the determination of the velocity of Ca2Â + waves, that is, arrhythmogenesis.
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Authors
Masahito Miura, Yuhto Taguchi, Tsuyoshi Nagano, Mai Sasaki, Tetsuya Handoh, Chiyohiko Shindoh,