Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8474279 | Journal of Molecular and Cellular Cardiology | 2015 | 12 Pages |
Abstract
These data reveal a novel interplay between the E2F pathway, β2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response. E2F6 deregulates E2F3 such that pro-hypertrophic growth and survival are enhanced via β2-adrenergic signaling however this response is outweighed by the induction of anti-hypertrophic signals so that left ventricle dilation proceeds without any increase in muscle mass.
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Authors
Jennifer L. Major, Maysoon Salih, Balwant S. Tuana,