| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474465 | Journal of Molecular and Cellular Cardiology | 2015 | 9 Pages |
Abstract
We were able to show that calcium-dependent PKC signaling is key to normal QT shortening during acute arousal and when impaired, correlates with increased rate of sudden arousal-triggered cardiac events. Our study suggests that the acute α1-AR-cPKC regulation of IKs is important for QT shortening in “fight-or-flight” response and is linked to decreased risk of sudden emotion/arousal-triggered cardiac events in LQT1 patients.
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Authors
Jin O-Uchi, J. Jeremy Rice, Martin H. Ruwald, Xiaorong Xu Parks, Elsa Ronzier, Arthur J. Moss, Wojciech Zareba, Coeli M. Lopes,