| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474483 | Journal of Molecular and Cellular Cardiology | 2015 | 9 Pages |
Abstract
Excessive delivery of FAs to the cardiac myocyte in the absence of systemic disorders leads to activation of lipid-driven signaling and remodeling of mitochondrial structure and function.
Keywords
CREBMetabolic heart diseaseSuccinate dehydrogenase subunit BFATP1mCATMHDSDHBPGC1αPKCADPACSPPARαacyl-CoA synthetaseROSAdenosine TriphosphateATPadenosine diphosphatesphingomyelinFatty acidsdiacylglycerolelectron transport chainCerceramideObesityMitochondriaElectron micrographsETccyclic AMP responsive element binding proteinfatty acid transport protein 1Protein kinase CReactive oxygen speciesperoxisome proliferator-activated receptor α
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Authors
Aly Elezaby, Aaron L. Sverdlov, Vivian H. Tu, Kanupriya Soni, Ivan Luptak, Fuzhong Qin, Marc Liesa, Orian S. Shirihai, Jamie Rimer, Jean E. Schaffer, Wilson S. Colucci, Edward J. Miller,