Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8474666 | Journal of Molecular and Cellular Cardiology | 2014 | 12 Pages |
Abstract
MCDâ/â mice consistently exhibited cardiac dysfunction and severe metabolic perturbations while on a high-fat, low carbohydrate diet of maternal milk and these gradually resolved post-weaning. This suggests that dysfunction is a common feature of MCD deficiency during early development, but that severity is dependent on composition of dietary substrates.
Keywords
ATG3PDK4β-MHCUCP3beta myosin heavy chainCPT-1GLUT4MCDGLUT1TANHDLCardiac dysfunctionFatty acidsFatty acid oxidationglucose transporter 4FAOlactate dehydrogenaseLDHhigh density lipoproteinlow density lipoproteinLDLMetabolismheart failureUncoupling protein 3Pyruvate dehydrogenase kinase 4carnitine palmitoyl transferase 1glucose transporter 1
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Authors
Dunja AksentijeviÄ, Debra J. McAndrew, Anja Karlstädt, Sevasti Zervou, Liam Sebag-Montefiore, Rebecca Cross, Gillian Douglas, Vera Regitz-Zagrosek, Gary D. Lopaschuk, Stefan Neubauer, Craig A. Lygate,