| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474702 | Journal of Molecular and Cellular Cardiology | 2014 | 5 Pages |
Abstract
Studies of transcriptional mechanisms in heart failure have focused heavily on roles of sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4. Recent findings have illuminated crucial functions for epigenetic regulators in the control of cardiac structural remodeling and mechanical dysfunction in response to pathological stress. Here, we review the current understanding of chromatin-dependent signal transduction in cardiac gene control, and highlight the potential for pharmacologic regulation of BET acetyl-lysine binding proteins as a means of treating heart failure.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Saptarsi M. Haldar, Timothy A. McKinsey,