| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8474844 | Journal of Molecular and Cellular Cardiology | 2014 | 9 Pages |
Abstract
MAFbx/Atrogin-1 is required for atrophic remodeling of the heart. During unloading, MAFbx/Atrogin-1 represses calcineurin-induced cardiac hypertrophy. Therefore, MAFbx/Atrogin-1 not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass.
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Authors
Kedryn K. Baskin, Meredith R. Rodriguez, Seema Kansara, Wenhao Chen, Sylvia Carranza, O. Howard Frazier, David J. Glass, Heinrich Taegtmeyer,