Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8474908 | Journal of Molecular and Cellular Cardiology | 2014 | 9 Pages |
Abstract
Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise approximately two-thirds of the total number of cardiac cell types. During development, epicardial cells undergo epithelial-mesenchymal-transition to generate cardiac fibroblasts that subsequently migrate into the developing myocardium to become resident cardiac fibroblasts. Fibroblasts form a structural scaffold for the attachment of cardiac cell types during development, express growth factors and cytokines and regulate proliferation of embryonic cardiomyocytes. In post natal life, cardiac fibroblasts play a critical role in orchestrating an injury response. Fibroblast activation and proliferation early after cardiac injury are critical for maintaining cardiac integrity and function, while the persistence of fibroblasts long after injury leads to chronic scarring and adverse ventricular remodeling. In this review, we discuss the physiologic function of the fibroblast during cardiac development and wound healing, molecular mediators of activation that could be possible targets for drug development for fibrosis and finally the use of reprogramming technologies for reversing scar. This article is part of a Special Issue entitled "Myocyte-Fibroblast Signalling in Myocardium."
Keywords
TGFmyocyte enhancer factorWilms tumor 1EndMTWT-1PDGFRPDGFECMRASCTGFMMPFGFMEFTbxWound HealingInfarctioninterleukinRemodelingtransforming growth factorRepairEMTTIMPRenin–angiotensin systemConnective tissue growth factorplatelet derived growth factorfibroblast growth factorT-box transcription factor FibroblastFibrosisExtracellular matrixmatrix metalloproteinaseTissue inhibitor of metalloproteinaseplatelet derived growth factor receptor
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Authors
Arjun Deb, Eric Ubil,