Article ID Journal Published Year Pages File Type
8475150 Journal of Molecular and Cellular Cardiology 2013 6 Pages PDF
Abstract
► NHE-1 inhibitors protect the ischemic and reperfused myocadium. ► Clinical trials have produced diverse results as well as evidence of adverse effects. ► The bases for clinical results can likely be rationalized based on various factors. ► NHE-1 inhibitors reduce heart failure and improve post-cardiac arrest resuscitation. ► Further development of NHE-1 inhibitors for cardiac therapeutics is warranted.
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