Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8475183 | Journal of Molecular and Cellular Cardiology | 2013 | 5 Pages |
Abstract
This study demonstrates that cMyBP-C harbors more phosphorylation sites than previously known, with a total of 17 (9 novel) identified phosphorylation sites in vivo. Most sites were primarily located within the N-terminal side of the protein. The most highly phosphorylated site on cMyBP-C was Ser284 and this site showed decreased phosphorylation in the failing heart, which implicates importance for fine-tuning contractility. To date, the functional importance of Ser286 and Thr290 is unknown. In addition, 16 sites were identified after in vitro kinase incubation. The data have been deposited to the ProteomeXchange with identifier PXD000158.
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Authors
Viola Kooij, Ronald J. Holewinski, Anne M. Murphy, Jennifer E. Van Eyk,