Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts

Article ID	Journal	Published Year	Pages	File Type
8475242	Journal of Molecular and Cellular Cardiology	2013	10 Pages	PDF

Abstract

âº EETs administered at ischemia or reperfusion reduce infarct size similarly. âº eNOS/NO signaling pathway mediates the cardioprotection of EETs at ischemia. âº At reperfusion, MPTP is an important mediator of the EET cardioprotective actions.

Keywords

Epoxyeicosatrienoic acids (EETs)Myocardial ischemia-reperfusion injury Mitochondrial permeability transition pore (mPTP)Endothelial nitric oxide synthase (eNOS)Nitric oxide (NO)