| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475244 | Journal of Molecular and Cellular Cardiology | 2013 | 11 Pages |
Abstract
⺠Ethanol intake by C57BL/6J mice increases cardiomyocyte fatty acid (FA) uptake. ⺠The increased FA uptake correlates with increased triglyceride (TG) content. ⺠Ethanol also down-regulates cardiac PGC-1α, the OX-PHOS pathway, and ATP. ⺠Ejection fraction correlates negatively with TGs and positively with ATP. ⺠This model mimics important features of human alcoholic cardiomyopathy.
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Authors
Chunguang Hu, Fengxia Ge, Eiichi Hyodo, Kotaro Arai, Shinichi Iwata, Harrison IV, José L. Walewski, Shengli Zhou, Robin D. Clugston, Hongfeng Jiang, Cynthia P. Zizola, Kalyani G. Bharadwaj, William S. Blaner, Shunichi Homma, P. Christian Schulze,