| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475245 | Journal of Molecular and Cellular Cardiology | 2013 | 14 Pages |
Abstract
⺠TMZ preserves cardiac function in the conditions of non-ischemic rabbit HF. ⺠The beneficial effect of TMZ was not linked to fatty acid oxidation inhibition. ⺠Cardioprotection by TMZ was mediated by prevention of Ca2 +-induced mPTP opening. ⺠The mechanism relies on re-coupling of the mitochondrial respiratory chain and mtNOS. ⺠Mild inhibition of the mitochondrial complex II by TMZ was beneficial in HF.
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Authors
Elena N. Dedkova, Lea K. Seidlmayer, Lothar A. Blatter,