| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475290 | Journal of Molecular and Cellular Cardiology | 2013 | 12 Pages |
Abstract
⺠Cardiomyocytes from failing hearts exhibit slow, dyssynchronous Ca2 + transients. ⺠T-tubule disorganization is known to de-synchronize Ca2 + release in failing cells. ⺠Dyssynchrony additionally results from a subset of Ca2 + sparks with slow kinetics. ⺠Slow sparks occur at intact dyads, not orphaned ryanodine receptors. ⺠Slow sparks are predicted to result from reorganization of Ca2 + release units.
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Authors
William E. Louch, Johan Hake, Halvor K. Mørk, Karina Hougen, Biljana Skrbic, Daniel Ursu, Theis Tønnessen, Ivar Sjaastad, Ole M. Sejersted,