| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475297 | Journal of Molecular and Cellular Cardiology | 2013 | 10 Pages |
Abstract
⺠CaV1.2 sparklets are local elevations in intracellular Ca2 + visualized with optics. ⺠CaV1.2 sparklet activity is heterogeneous in cardiac and smooth muscle cells. ⺠CaV1.2 sparklets are locally controlled by a signaling hub coordinated by AKAP150. ⺠Cluster of CaV1.2 channels can open and close in unison (i.e., coupled gating). ⺠Coupled gating amplifies Ca2 + influx in cardiac and smooth muscle.
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Authors
Manuel F. Navedo, Luis F. Santana,