| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475300 | Journal of Molecular and Cellular Cardiology | 2013 | 7 Pages |
Abstract
⺠CICR is counterbalanced by store-dependent deactivation due to reciprocal decrease in [Ca2 +]SR. ⺠RyR2 regulation by luminal Ca2 + is mediated by CASQ2 inhibiting RyR2 at low luminal Ca2 +. ⺠Luminal Ca2 + allosterically modulates RyR2 sensitivity to cytosolic Ca2 +. ⺠Genetic and acquired defects in RyR2 complex dysregulate store-dependent deactivation. ⺠Impairment of store-dependent deactivation results in cardiac arrhythmias.
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Authors
PrzemysÅaw B. RadwaÅski, Andriy E. Belevych, Lucia Brunello, Cynthia A. Carnes, Sándor Györke,