| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475318 | Journal of Molecular and Cellular Cardiology | 2013 | 10 Pages |
Abstract
⺠Ca2 + influx by L-type Ca2 + channels trigger Ca2 + release and cardiac contraction. ⺠We discuss how VGCC are regulated by GPCR via cAMP/PKA. ⺠VGCC form signaling complexes with β2AR, Gs, adenylyl cyclase, and PKA. ⺠VGCC also associate with the protein phosphatases PP2A and PP2B. ⺠These complexes regulate channel activity in a highly localized manner.
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Authors
Robert D. Harvey, Johannes W. Hell,