| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475323 | Journal of Molecular and Cellular Cardiology | 2013 | 10 Pages |
Abstract
⺠Epac is an exchange protein directly activated by cAMP. ⺠Epac increases Ca2 + spark rate and intranuclear Ca2 + in ventricular cardiac myocytes. ⺠PLC, PKC, CaMKII, IP3, and calcineurin are involved in Epac actions. ⺠Epac induces HDAC5 translocation, MEF2 activation and calmodulin upregulation. ⺠Epac affects excitation-contraction and excitation-transcription coupling.
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Authors
Gema Ruiz-Hurtado, Eric Morel, Alejandro DomÃnguez-RodrÃguez, Anna Llach, Frank Lezoualc'h, Jean-Pierre Benitah, Ana M. Gomez,