Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8475350 | Journal of Molecular and Cellular Cardiology | 2013 | 10 Pages |
Abstract
The changes seen when phosphorylation of sarcomeric proteins in myocardium of affected patients is matched to control tissue suggest that the R723G mutation causes reduced Ca++-sensitivity in both cardiomyocytes and M. soleus fibers. In MyHC723-myocardium, however, hypophosphorylation can compensate for the reduced calcium-sensitivity, while maximum force generation, lowered by myofibrillar deficiency and disarray, remains impaired, and may only be compensated by hypertrophy.
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Authors
Theresia Kraft, E. Rosalie Witjas-Paalberends, Nicky M. Boontje, Snigdha Tripathi, Almuth Brandis, Judith Montag, Julie L. Hodgkinson, Antonio Francino, Francisco Navarro-Lopez, Bernhard Brenner, Ger J.M. Stienen, Jolanda van der Velden,