| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475354 | Journal of Molecular and Cellular Cardiology | 2013 | 12 Pages |
Abstract
⺠A decline in LV contractility in VO HF is coincident with that of LV myocytes. ⺠[Ca2 +]i levels were offset by EC coupling proteins with no net effect on function. ⺠Changes in myofilament proteins contribute to reduced contractility in HF. ⺠β-AR responsiveness was decreased in vivo HF but preserved in isolated myocytes. ⺠Reduced connexin-43 contributes to altered basal and β-AR responsiveness in VO HF.
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Authors
Anuradha Guggilam, Kirk R. Hutchinson, T. Aaron West, Amy P. Kelly, Maarten L. Galantowicz, Amy J. Davidoff, Sakthivel Sadayappan, Pamela A. Lucchesi,