| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475361 | Journal of Molecular and Cellular Cardiology | 2013 | 10 Pages |
Abstract
⺠8-CPT-AM, a new membrane-permeant selective activator, was used to activate Epac. ⺠8-CPT-AM prolonged action potential, without change in other parameters. ⺠Action potential prolongation by Epac is due to a decrease in sustained K+ current. ⺠β-AR stimulation with PKA inhibition mimicked 8-CPT-AM effect on action potential.
Keywords
ICAcyclic adenosine 3′, 5′-monophosphateExchange proteins directly activated by cAMPPLBGEFEpacRyRISSPDEpKacAMPISOIsoprenalineITOPotassium currentTransient outward potassium currentDelayed rectifier potassium currentcalcium currentL-type calcium currentGuanine nucleotide exchange factorsPhosphodiesterasesphospholambanCardiac myocyteaction potentialcAMP-dependent protein kinaseRyanodine receptor
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Authors
Fabien Brette, Erick Blandin, Christophe Simard, Romain Guinamard, Laurent Sallé,