Article ID Journal Published Year Pages File Type
8475367 Journal of Molecular and Cellular Cardiology 2013 10 Pages PDF
Abstract
► We studied the effects of training/detraining on the cardiomyocyte function of SHR. ► Hypertension resulted in deficient cardiomyocyte contractile function. ► Exercise improved cardiomyocyte [Ca2 +]i transient and contractile function in SHR. ► These benefits were related to increased PLBser16 and SERCA2a cardiac expression. ► Such exercise training-induced adaptations were reversed within 4 weeks of detraining.
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