| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475377 | Journal of Molecular and Cellular Cardiology | 2013 | 11 Pages |
Abstract
⺠Diastolic dysfunction is associated with reduced cross-bridge kinetics. ⺠The reduced cross-bridge kinetics is associated with S-glutathionylation of MyBP-C. ⺠BH4 treatment reversed reduced cross-bridge kinetics and diastolic dysfunction. ⺠The effect of BH4 correlated with a reduction in S-glutathionylation of MyBP-C. ⺠BH4 treatment may work by preventing this oxidative modification.
Keywords
BDMN-ethylmaleimidecardiac myosin binding protein-CNOSCa2 + sensitivitycTnIMyBP-CTDIDOCAS-glutathionylationBH4tetrahydrobiopterin2,3-Butanedione monoximeleft ventricleTroponin TTissue Doppler imagingOxidative stressTnTdeoxycorticosterone acetatecardiac troponin IDiastolic heart failureNEMNitric oxidenitric oxide synthaseProtein kinaseejection fractionfractional shortening
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Authors
Euy-Myoung Jeong, Michelle M. Monasky, Lianzhi Gu, Domenico M. Taglieri, Bindiya G. Patel, Hong Liu, Qiongying Wang, Ian Greener, Samuel C. Jr., R. John Solaro,