| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475412 | Journal of Molecular and Cellular Cardiology | 2013 | 4 Pages |
Abstract
⺠Mice were fed perhexiline to achieve steady state concentrations. ⺠Hearts were analysed using a combined proteomic and metabolomic approach. ⺠Computer modelling was used to cross-validate the findings. ⺠Perhexiline has more wide-ranging and complex metabolic effects than previously thought.
Keywords
FCSCPTFDRTCA1H NMRLC-MS/MStricarboxylic acidDifference in-gel electrophoresisCardioprotectionDIGEfoetal calf serumproton nuclear magnetic resonance spectroscopyMetabolomicsMetabolismfalse discovery rateheart failureGene ontologyProteomicsCarnitine palmitoyltransferaseliquid chromatography tandem mass spectrometry
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Authors
Xiaoke Yin, Joseph Dwyer, Sarah R. Langley, Ursula Mayr, Qiuru Xing, Ignat Drozdov, Adam Nabeebaccus, Ajay M. Shah, Basetti Madhu, John Griffiths, Lindsay M. Edwards, Manuel Mayr,