Article ID Journal Published Year Pages File Type
8475424 Journal of Molecular and Cellular Cardiology 2013 12 Pages PDF
Abstract
► Protein quality control minimizes the level and toxicity of misfolded proteins. ► Failing human hearts often display protein quality control inadequacy. ► Substrate delivery to the proteasome appears to be deficient in diseased hearts. ► Ubiquitin receptors help deliver ubiquitinated proteins to the proteasome. ► The role of ubiquitin receptors in cardiac (patho)physiology is yet to be defined.
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