Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC

► Cardiac hypertrophy is a major risk factor for adverse cardiovascular events and death. ► Hypertrophy is physiological as with exercise or pathological as with hypertension. ► We discuss recent developments in 3 areas fundamental to pathological cardiac hypertrophy. ► Recent studies on TRPC channels, mTOR, and HDAC enzymes provide new clues into cardiac hypertrophy.