| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8475461 | Journal of Molecular and Cellular Cardiology | 2011 | 10 Pages |
Abstract
⺠Yeast two-hybrid screening revealed Zfp90 as a novel NRSF-binding protein. ⺠Zfp90 attenuated the repressor activity of NRSF by inhibiting its binding to DNA. ⺠Knockdown of Zfp90 in cardiac myocytes led to reduced expression of ANP and BNP genes. ⺠Overexpression of Zfp90 in ventricular myocardium increased the expression of ANP and BNP genes. ⺠Expression of Zfp90 mRNA was significantly upregulated in mouse and human failing hearts.
Keywords
FBSLSD1NRSFZFPNRSEBNPMecp2ChFDMEMHDACDBDsarco/endoplasmic reticulum Ca2+ ATPaseANPDulbecco's modified Eagle's mediumMyocardial infarctionlysine-specific demethylase 1Zinc-fingerCardiac remodelingfetal gene programthymidine kinaseDNA-Binding DomainTranscriptionRILPMyosin heavy chainfetal bovine serumneuron-restrictive silencer factorneuron-restrictive silencer elementSERCAMHCYeast-two hybridChronic heart failurehistone deacetylaseZinc finger proteinbrain natriuretic peptideatrial natriuretic peptide
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Authors
Leo Hata, Masao Murakami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Satoru Usami, Shinji Yasuno, Masataka Fujiwara, Yoshihiro Kuwabara, Takeya Minami, Yuko Yamada, Chinatsu Yamada, Kazuhiro Nakao, Kenji Ueshima, Toshio Nishikimi,