Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis

► We studied the effects of exercise on cardiac function in mice with aortic stenosis. ► Mild aortic stenosis resulted in compensated cardiac hypertrophy. ► Severe aortic stenosis resulted in cardiac hypertrophy and dysfunction. ► Exercise failed to improve cardiac function in mice with mild or severe aortic stenosis.